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Disseminated Langerhans' cell histiocytosis and massive protein-losing enteropathy BJMBR
Santos-Machado,T.M.; Cristófani,L.M.; Almeida,M.T.A.; Maluf,P.T.; Costa,P.A.; Pereira,M.A.; Brito,J.L.B.C.; Odone-Filho,V..
Symptomatic involvement of the gastrointestinal (GI) tract as a prominent symptom in Langerhans' cell histiocytosis (LCH) is uncommon, occurring in less than 1 to 5% of all cases, even when the disease is in its disseminated form. Up to now, there have been reports of 18 cases of LCH with GI manifestations, including our 2 cases, with diarrhea (77.7%), protein-losing enteropathy (33.3%) and bloody stool being the most frequent findings. The authors present two patients with severe diarrhea and refractory hypoalbuminemia, and with the protein-losing enteropathy documented by Cr51-labeled albumin studies. A review of the literature indicated that the presence of GI symptoms is often associated with systemic disease as well as with poor prognosis, mainly...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Langerhans' cell histiocytosis; Histiocytosis X; Gastrointestinal involvement; Protein-losing enteropathy; Hypoalbuminemia; Cr51-labeled albumin test.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900007
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Increase in skeletal muscle protein content by the ß-2 selective adrenergic agonist clenbuterol exacerbates hypoalbuminemia in rats fed a low-protein diet BJMBR
Sawaya,A.L.; Lunn,P.G..
This investigation examined how the nutritional status of rats fed a low-protein diet was affected when the animals were treated with the ß-2 selective agonist clenbuterol (CL). Males (4 weeks old) from an inbred, specific-pathogen-free strain of hooded rats maintained at the Dunn Nutritional Laboratory were used in the experiments (N = 6 rats per group). CL treatment (Ventipulmin, Boehringer-Ingelheim Ltd., 3.2 mg/kg diet for 2 weeks) caused an exacerbation of the symptoms associated with protein deficiency in rats. Plasma albumin concentrations, already low in rats fed a low-protein diet (group A), were further reduced in CL rats (A = 25.05 ± 0.31 vs CL = 23.64 ± 0.30 g/l, P<0.05). Total liver protein decreased below the level seen in either...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Protein-energy malnutrition; Rats; Clenbuterol; Hypoalbuminemia; Brown adipose tissue; SS-2 agonist.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000600015
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